Strategic attributes likely to face headwinds

An excerpt from Fisher investments -“Portfolio drivers help determine which kind of strategic attributes are likely to face head - or tailwinds. After all, not all strategic attributes will benefit a firm in all environments.”

How can certain strategic attributes (moats) can turn out to be disadvantageous !!! Can you give some examples to prove the point?

Yes I am a beginner and all I knew till day that moats only add to the advantages to a company…