This is a very personal question. It not just depends on the assets (which in itself is a question), it also depends a lot of factors, quantitative and non-quantitative. There is mathematics involved as far as expenses and spending are concerned, but there are many other aspects involved, including one’s own psychology, social life, utilization of time, introspection etc.
Check this thread, it is about equity, but it provides a picture. There are members who left their jobs (for whatever reasons), and how their perceives changed/unchanged after leaving their jobs.
If you are absolute, nothing will beat the joy of having your time for what you want to do, the way you want to do.
P.S Typed this, found what you do, still posting this. 